The course takes you on a science-based drug discovery journey. You will travel from inception of a new project to the point of hand-over of the newly discovered molecule to the Development Team for pre-clinical and clinical studies. The course breaks down the long, multi-faceted discovery process into individual steps which build towards this key goal. The focus is on how essential science, technology and infrastructure elements are constituted, deployed and integrated to maximise the likelihood of a successful discovery project.
26-27 Jan 2023
+ 2 more dates
Drug discovery is a compelling mixture of established science and new, cutting-edge developments. It is powered by the know-how of its stakeholders and a long history which provide us with guidance on the scientific path for a successful project. The disciplines required include Biology, Biochemistry, Molecular Biology, Medicinal Chemistry and Informatics (and their sub-disciplines) with the support of major infrastructure and extensive non-scientific functions (Management, Financial, Commercial, Legal etc). All involved must work in harmony over a long timescale to successfully reach the final goal. This course has been designed to steer you through the process and focuses on small molecule drug discovery, making some reference to biologics.
Each company carries out drug discovery in a unique manner and the process continually evolves; however, there is a ‘Classical Model’ that is often followed and will be presented here. The programme describes how the project begins by selecting the disease to be treated, and then identifying a protein target whose modulation by a compound or biologic will have the required therapeutic effect based on the molecular mechanism of the disease. A large number of compounds or biologics are then generated and iteratively optimised for a wide range of key chemical, physical and biological attributes based on past experience. A lead (or lead series) of compounds is eventually selected which is further optimised to generate the clinical candidate. The science base and phasing of these activities will be covered together with the realities of the Pharma - Biotech environment in which they occur.
This is an excellent opportunity to engage with the drug discovery process and the elements involved with an expert in this field. The course will include a number of interactive exercises to aid the learning experience.
Gain an understanding of the:
Typical drug discovery considerations:
How to select the right protein drug target for the disease:
The path to obtaining a lead or lead series with the quality attributes to become a clinical candidate. An outline of the key scientific tools of drug discovery:
In vitro ADMET methodologies and their application:
Final ‘polishing’ of the lead with a view to its nomination to enter Pre-clinical and Preclinical Development:
After a Ph.D and postdoctoral positions in the UK and USA in protein biochemistry Peter joined Celltech (now part of UCB Pharma). There he was involved in biologics discovery. His next relevant position was with Roche where he became a senior manager in Biological Technology discovering small molecule antiviral drugs against HIV, Flu and Hepatitis C. Peter then went on to leadership positions in small/mid-sized Biotech companies in the UK and Switzerland before starting a Pharma-Biotech consultancy based near Cambridge, UK.
NEW higher discounts for multiple bookings - bring your colleagues to make your training budget go further:
Please contact us for pricing if you are interested in booking 5 or more delegates
26-27 Jan 2023
09:30-17:00 UK (London) (UTC+00)
10:30-18:00 Paris (UTC+01)
04:30-12:00 New York (UTC-05)
Course code 12859
Until 22 Dec
11-12 May 2023
09:00-17:00 UK (London)
Course code 12852
Until 06 Apr
21-22 Sep 2023
09:30-17:00 UK (London) (UTC+01)
10:30-18:00 Paris (UTC+02)
04:30-12:00 New York (UTC-04)
Course code 12853
Until 17 Aug
* Early booking discounts may not be combined with other discounts or offers. As such, the discounts for 2nd/3rd/4th delegates are based on the full price.
Multiple colleagues? See above for details of our discounts for 2, 3, or 4 delegates. For more, talk to one of our training experts to discuss how to: